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  • December 19th, 2010

    Nci Drug Information System

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    NCI Drug Information System

    The NCI Drug Information System (DIS) was set up in 1980 to record the acquisition, storage, shipping and testing of drugs at the National Cancer Institute. The NCI has been conducting extensive research and testing of materials as possible actors against different varieties of cancer. The data generated by these activities was huge and hence the NCI DIS was created to take care of all aspects related to data. The National Cancer Institute Drug Information System is, therefore, a searchable database of 3 dimensional structures that have been developed from its chemistry database – a file of about 4,50,000 primarily organic compounds that have been tested by the NCI for anti cancer activity.

    The DIS is made up of 2 major sub systems, the Pre Registry and the Drug Sub – Systems. The former is connected with only acquisition of compounds. The Drug Sub – system is the one used by most users and is the location where most of the data is stored. This includes a database for Chemistry, Biology, Test Systems, Minutes of Meetings, Name Codes, Vehicle Codes, Geographic Codes, Inventory, Acquisition Category Codes and details of Orders and Shipping. The 3 D database has applications like 3 D pharmacophore searches to discover novel active compounds and statistical investigations using 3D distance keys.

    Drug Tests check a person for the use of drugs. To pass drug test you need to know some basic details of drugs and drug tests. The most commonly used drugs are marijuana that is the most popular, opiates, amphetamine, methamphetamine, benzodiazepine, PCP, cocaine, ecstasy and the like. A drug test can be a urine test, a blood test, saliva test, hair test or sweat test depending on the sample used for detection of drug residues. Opiates are derived from the opium poppy plant. The average time for which the human body retains them depends on the percentage of body fat (as they are fat soluble), the amount of drug used in each installment and the frequency of drug use. The urine test is usually used to detect opiates. So opiate drug detoxification is similar to detox for a urine test viz. fat burning exercise, drinking a lot of water and eating a balanced diet for 7 to 15 days before the test.

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