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February 16th, 2011
Autonomic Nervous System Drug Responses
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What are the autonomic nervous system drug responses?
Talking about autonomic nervous system drug responses, automatic nervous system can regulate body processes like rate of breathing as well as blood pressure. The system acts in an automatic way without the conscious attempt of an individual. Disorders of autonomic nervous system may affect any body part. Automatic disorder can result from other disorders, which injure autonomic nerves or they can come on their own. Automatic disorder can be reversible. Volunteers attained either placebo or low dose dexmedetomidine infusions in a prospectively randomized crossover study design. After one hour, baroreflex sensitivity was evaluated and core body temperature as well as blood pressure was also calculated and cardiac automatic replies were evaluated by analysis of heart rate variability.
As compared to placebo, plasma norepinephrine concentrations, heart rate, blood pressure as well as heart rate variability can calculate were low after one hour infusion of dexmedetomidine however replies did not vary crucially. Dexmedetomidine blunted systemic as well as cardiac sympathetic effects of sweating examined during placebo infusion however had no effect on parasympathetic measures. Systemic catecholamines as well as increase in blood pressure because of shivering were also examined during placebo however such responses were less with dexmedetomidine. Dexmedetomidine infusion during shivering was linked with great low frequency as well as great heart rate variability power however lessen heart rate as compared to sweating threshold and with control period, advising nonreciprocal cardiac autonomic responses.
Infusion of dexmedetomidine can result in compensated lessening in systematic sympathetic tone without alterations in baroreflex sensitivity. Dexmedetomidine blunts heart rate as well as systematic sympathetic activation because of sweating however it is less efficient in blunting cardiac sympathetic replies to shivering. Anesthetics are drugs, which encourage a temporary for perceiving any sensory stimuli. They accomplish such effect by working on brain or peripheral nervous system for suppressing replies to sensory stimulation, primarily to pain, touch and pressure. Unresponsive state that is induced by anesthetic drugs is named as anesthesia. Usual anesthetics encourage anesthesia throughout body and may be administered by inhalation.
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